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Human Studies In a human abuse liability study, when equivalent oral modération of 100 mg lisdexamfetamine dimesylate and 40 mg immediate-release d-amphetamine sulfate were administered to individuals with a history of drug abuse, lisdexamfetamine dimesylate 100 mg produced subjective responses on a scale of "Drug Liking Effects" (primary endpoint) that were significantly less than d-amphetamine immediate-release 40 mg. However, oral économie of 150 mg lisdexamfetamine dimesylate produced increases in patente subjective responses on this scale that were statistically indistinguishable from the patente subjective responses produced by 40 mg of oral immediate-release d-amphetamine and 200 mg of diethylpropion (C-IV).
12.1 Mechanism of Fait Lisdexamfetamine is a prodrug of dextroamphetamine. After oral gérance, lisdexamfetamine is rapidly absorbed from the gastrointestinal tract and converted primarily in blood due to the hydrolytic activity of red Cruor cells to dextroamphetamine, which is responsible expérience the drug's activity. Amphetamines are non-catecholamine sympathomimetic amines with CNS stimulant activity.
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